Miga1 Gene Summary [Mouse]
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Predicted to be located in mitochondrion and plasma membrane. Is expressed in brain; metanephros; spinal cord; and testis. Orthologous to human MIGA1 (mitoguardin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Miga1 |
| Official Name | mitoguardin 1 [Source:MGI Symbol;Acc:MGI:1924567] |
| Ensembl ID | ENSMUSG00000054942 |
| Bio databases IDs | |
| Aliases | mitoguardin 1 |
| Synonyms | A930038D06, AI852168, C030011O14Rik, FAM73A, Mita1, mitoguardin 1, RGD1559958 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Miga1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitoguardin
- protein homodimerization
- protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- COVID-19
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung carcinoma
- lung carcinoma process
role in cell
- fusion
- phosphorylation in
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Miga1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial fusion
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- protein heterodimerization activity