Dynll1 Gene Summary [Mouse]
Enables dynein intermediate chain binding activity and protein domain specific binding activity. Acts upstream of or within several processes, including cilium organization; mitocytosis; and positive regulation of non-motile cilium assembly. Located in cytoskeleton; cytosol; and membrane. Part of cytoplasmic dynein complex. Is expressed in several structures, including central nervous system; liver; lung; node; and sensory organ. Orthologous to human DYNLL1 (dynein light chain LC8-type 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dynll1 |
| Official Name | dynein light chain LC8-type 1 [Source:MGI Symbol;Acc:MGI:1861457] |
| Ensembl ID | ENSMUSG00000009013 |
| Bio databases IDs | |
| Aliases | dynein light chain LC8-type 1 |
| Synonyms | 8kDLC, Cytoplasmic dynein, light chain, DLC1, DLC8, DNCL1, DNCLC1, dynein light chain LC8-type 1, Dynll4, hdlc1, LC8, LC8a, LC8 DYNEIN LIGHT CHAIN, PIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dynll1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PLN03058
- binding protein
- nitric oxide synthase regulator
- Dynein light chain type 1
- enzyme inhibitor activity
- dynein light chain (DLC)-like domain superfamily
- dynein intermediate chain binding
- enzyme binding
- protein domain specific binding
- protein binding
- identical protein binding
- phosphorylation site
Pathways
Biological processes and signaling networks where the Dynll1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- lichen planus
- tumorigenesis
- endometriosis
- systemic juvenile idiopathic arthritis
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- quantity
- activation in
- differentiation
- formation
- transformation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ciliary tip
- cytoskeleton
- cilia
- cellular membrane
- filamentous network
- Nucleus
- Plasma Membrane
- vesicles
- centrosome
- Mitochondria
- secretory granule membrane
- granules
- microtubule organizing centers
- tertiary granule membrane
- cytosol
- growth cone
- secretory granules
- cellular protrusions
- mitotic spindle
- kinetochores
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dynll1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- apoptotic process
- response to DNA damage stimulus
- motile cilium assembly
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- intraflagellar retrograde transport
- substantia nigra development
- negative regulation of phosphorylation
- negative regulation of nitric oxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- site of double-strand break
- kinetochore
- plasma membrane
- microtubule
- nucleus
- centrosome
- cytoplasmic dynein complex
- cytoskeleton
- mitotic spindle
- cytoplasm
- membrane
- mitochondrion
- cilium
- dynein complex
- cytosol
- signalosome
- tertiary granule membrane
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- identical protein binding
- protein binding
- enzyme inhibitor activity
- deoxyribonuclease inhibitor activity
- dynein intermediate chain binding
- enzyme binding