Pgpep1 Gene Summary [Mouse]
Predicted to enable peptidase activity. Predicted to be involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol. Is expressed in central nervous system; genitourinary system; gut; lung; and submandibular gland primordium. Orthologous to human PGPEP1 (pyroglutamyl-peptidase I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgpep1 |
| Official Name | pyroglutamyl-peptidase I [Source:MGI Symbol;Acc:MGI:1913772] |
| Ensembl ID | ENSMUSG00000056204 |
| Bio databases IDs | |
| Aliases | pyroglutamyl-peptidase I |
| Synonyms | 2810003H13RIK, Gm19458, LOC100502927, MGC10812, PAP-I, Pcp, PGI, PGP, PGP-I, pyroglutamyl-peptidase I |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgpep1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- protein binding
- pyroglutamyl-peptidase I
- Peptidase_C15
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgpep1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein catabolic process
- proteolysis
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyroglutamyl-peptidase activity