Trim11 Gene Summary [Mouse]
Enables protein domain specific binding activity and ubiquitin protein ligase activity. Involved in several processes, including defense response to other organism; negative regulation of viral transcription; and positive regulation of viral entry into host cell. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; hemolymphoid system gland; nervous system; submandibular gland primordium; and urinary system. Orthologous to human TRIM11 (tripartite motif containing 11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim11 |
| Official Name | tripartite motif-containing 11 [Source:MGI Symbol;Acc:MGI:2137355] |
| Ensembl ID | ENSMUSG00000020455 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 11 |
| Synonyms | BIA1, RNF92, tripartite motif-containing 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- protein binding activity, bridging
- transcription factor binding
- coiled-coil domain
- protein domain specific binding
- enzyme
- Ring finger domain
- protein binding
- B30.2 domain
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- B-box zinc finger
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- polyglandular autoimmune syndrome type 1
- progressive supranuclear palsy
role in cell
- proliferation
- degradation in
- migration
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- negative regulation of viral entry into host cell
- innate immune response
- regulation of gene expression
- positive regulation of viral entry into host cell
- negative regulation of neurogenesis
- protein autoubiquitination
- protein ubiquitination
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein domain specific binding
- protein binding
- protein binding, bridging