Ier5 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including cellular response to heat; positive regulation of cellular response to heat; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be part of protein phosphatase type 2A complex. Is expressed in several structures, including branchial arch; central nervous system; forelimb bud; retina; and somite. Orthologous to human IER5 (immediate early response 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ier5 |
| Official Name | immediate early response 5 [Source:MGI Symbol;Acc:MGI:1337072] |
| Ensembl ID | ENSMUSG00000056708 |
| Bio databases IDs | |
| Aliases | immediate early response 5 |
| Synonyms | immediate early response 5, SBBI48, Similar to ier5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ier5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- Immediate early response protein (IER)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- IER5
regulated by
- TP53
- hydrogen peroxide
- lipopolysaccharide
- sirolimus
- isoprenaline
- mir-483
- CPI203
- Mycobacterium tuberculosis H37Rv
- SETD7
- 5-fluorouracil
disease
- latent tuberculosis
- Huntington disease
role in cell
- proliferation
- expression in
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ier5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to heat
- positive regulation of cellular response to heat
- positive regulation of transcription from RNA polymerase II promoter
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- protein phosphatase type 2A complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding