Ppp2r2c Gene Summary [Mouse]
Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Is expressed in cortical plate; inner cell mass; pelvic ganglion; urethra of female; and urethra of male. Orthologous to human PPP2R2C (protein phosphatase 2 regulatory subunit Bgamma). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp2r2c |
| Official Name | protein phosphatase 2, regulatory subunit B, gamma [Source:MGI Symbol;Acc:MGI:2442660] |
| Ensembl ID | ENSMUSG00000029120 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2, regulatory subunit B, gamma |
| Synonyms | 6330548O06RIK, B55-GAMMA, B55-γ, IMYPNO, IMYPNO1, LOC103693768, PP2A-Bgamma, PR52, PR55G, protein phosphatase 2 regulatory subunit Bgamma, protein phosphatase 2, regulatory subunit B, gamma, protein phosphatase 2, regulatory subunit B, γ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp2r2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoprotein phosphatase
- phosphatase
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Ppp2r2c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Cellular Effects of Sildenafil (Viagra)
- Ceramide Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
- insomnia
- colorectal cancer
- diabetic nephropathy
- peripheral arterial disease
- metastatic prostate cancer
- idiopathic scoliosis
- scarlet fever
role in cell
- migration
- expression in
- proliferation
- phosphorylation in
- upregulation in
- outgrowth
- binding in
- growth
- dephosphorylation in
- neuritogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp2r2c gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytosol
- protein phosphatase type 2A complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase regulator activity