IER5 Gene Summary [Human]
This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IER5 |
| Official Name | immediate early response 5 [Source:HGNC Symbol;Acc:HGNC:5393] |
| Ensembl ID | ENSG00000162783 |
| Bio databases IDs | |
| Aliases | immediate early response 5 |
| Synonyms | immediate early response 5, SBBI48, Similar to ier5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IER5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- Immediate early response protein (IER)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- IER5
disease
- latent tuberculosis
- Huntington disease
role in cell
- proliferation
- expression in
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IER5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to heat
- positive regulation of cellular response to heat
- positive regulation of transcription from RNA polymerase II promoter
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- protein phosphatase type 2A complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding