Kcnj14 Gene Summary [Mouse]

Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to be located in dendrite and neuronal cell body. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; jaw; limb; nervous system; and oral epithelium. Orthologous to human KCNJ14 (potassium inwardly rectifying channel subfamily J member 14). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Kcnj14
Official Name
potassium inwardly-rectifying channel, subfamily J, member 14 [Source:MGI Symbol;Acc:MGI:2384820]
Ensembl ID
ENSMUSG00000058743
Bio databases IDs NCBI: 211480 Ensembl: ENSMUSG00000058743
Aliases potassium inwardly-rectifying channel, subfamily J, member 14
Synonyms A930026G01Rik, IRK4, KIR2.4, potassium inwardly rectifying channel subfamily J member 14, potassium inwardly-rectifying channel, subfamily J, member 14
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnj14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • inward rectifier potassium channel
  • Inward rectifier potassium channel C-terminal domain
  • Inward rectifier potassium channel transmembrane domain
  • ion channel

Pathways

Biological processes and signaling networks where the Kcnj14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • colorectal cancer
  • organismal death
  • hypothyroidism
regulated by
role in cell
  • proliferation
  • migration
  • invasion by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • perikaryon
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnj14 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of ion transmembrane transport

Cellular Component

Where in the cell the gene product is active
  • dendrite
  • voltage-gated potassium channel complex
  • neuronal cell body
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • inward rectifier potassium channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.