Kcnj14 Gene Summary [Rat]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]

Details

Type
Protein Coding
Official Symbol
Kcnj14
Official Name
potassium inwardly-rectifying channel, subfamily J, member 14 [Source:RGD Symbol;Acc:628872]
Ensembl ID
ENSRNOG00000021056
Bio databases IDs NCBI: 276720 Ensembl: ENSRNOG00000021056
Aliases potassium inwardly-rectifying channel, subfamily J, member 14
Synonyms A930026G01Rik, IRK4, KIR2.4, potassium inwardly rectifying channel subfamily J member 14, potassium inwardly-rectifying channel, subfamily J, member 14
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnj14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • inward rectifier potassium channel
  • Inward rectifier potassium channel C-terminal domain
  • Inward rectifier potassium channel transmembrane domain
  • ion channel

Pathways

Biological processes and signaling networks where the Kcnj14 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • colorectal cancer
  • organismal death
  • hypothyroidism
regulated by
role in cell
  • proliferation
  • migration
  • invasion by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • perikaryon
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnj14 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of ion transmembrane transport

Cellular Component

Where in the cell the gene product is active
  • dendrite
  • voltage-gated potassium channel complex
  • neuronal cell body
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • inward rectifier potassium channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.