Kcnh7 Gene Summary [Mouse]
Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including heart; nervous system; retina; skeletal muscle; and skin. Orthologous to human KCNH7 (potassium voltage-gated channel subfamily H member 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnh7 |
| Official Name | potassium voltage-gated channel, subfamily H (eag-related), member 7 [Source:MGI Symbol;Acc:MGI:2159566] |
| Ensembl ID | ENSMUSG00000059742 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, subfamily H (eag-related), member 7 |
| Synonyms | 9330137I11Rik, ERG3, HERG3, Kv11.3, potassium voltage-gated channel, subfamily H (eag-related), member 7, potassium voltage-gated channel subfamily H member 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnh7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- inward rectifier potassium channel
- Ion transport protein
- PAS domain S-box
- PAS
- heme binding
- ion channel
- PAS fold
- Cyclic nucleotide-monophosphate binding domain
- Cyclic nucleotide-binding domain
- voltage-gated potassium channel
- binding protein
- PAS domain
- CAP_ED
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- cardiovascular disorder
- irritable behavior
- non-insulin-dependent diabetes mellitus
- malaria
- coronary artery disease
- atrial flutter
- stroke
- Alzheimer disease
- heart disease
regulated by
- verapamil
- dofetilide
- quinidine
- procainamide
regulates
- K+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnh7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of membrane potential
- potassium ion transmembrane transport
- circadian rhythm
Cellular Component
Where in the cell the gene product is active
- ion channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- inward rectifier potassium channel activity