Lrsam1 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of macroautophagy; protein ubiquitination; and ubiquitin-dependent endocytosis. Predicted to be located in cytosol and membrane. Is expressed in cranial ganglion; dorsal root ganglion; hindbrain; and olfactory epithelium. Used to study Charcot-Marie-Tooth disease axonal type 2P. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2P. Orthologous to human LRSAM1 (leucine rich repeat and sterile alpha motif containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrsam1 |
| Official Name | leucine rich repeat and sterile alpha motif containing 1 [Source:MGI Symbol;Acc:MGI:2684789] |
| Ensembl ID | ENSMUSG00000026792 |
| Bio databases IDs | |
| Aliases | leucine rich repeat and sterile alpha motif containing 1 |
| Synonyms | CMT2G, CMT2P, leucine rich repeat and sterile alpha motif containing 1, leucine rich repeat and sterile α motif containing 1, RGD1564403, RIFLE, TAL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrsam1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ermad domain
- Tropomyosin like
- SAM (Sterile alpha motif )
- ubiquitin protein ligase activity
- SAM domain
- Leucine rich repeat
- coiled-coil domain
- enzyme
- PSAP motif
- protein binding
- tandem tetrapeptide motif
- Sterile alpha motif
- leucine-rich repeat
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- SAM domain (Sterile alpha motif)
- PTAP motif
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrsam1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquitin-dependent endocytosis
- negative regulation of endocytosis
- autophagy
- protein catabolic process
- protein polyubiquitination
- non-lytic virus budding
- positive regulation of autophagic vacuole assembly
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding