Ang4 Gene Summary [Mouse]
Enables RNA nuclease activity. Involved in several processes, including angiogenesis; cellular response to lipopolysaccharide; and defense response to symbiont. Acts upstream of or within antibacterial humoral response. Located in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ang4 |
| Official Name | angiogenin, ribonuclease A family, member 4 [Source:MGI Symbol;Acc:MGI:2656551] |
| Ensembl ID | ENSMUSG00000060615 |
| Bio databases IDs | |
| Aliases | angiogenin, ribonuclease A family, member 4 |
| Synonyms | angiogenin, ribonuclease A family, member 4, Raa4, Rnase5d |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ang4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- peptide binding
- ribonuclease
- actin binding
- protein homodimerization
- enzyme
- receptor binding
- RNase_A
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- actin cytoskeleton
- Nucleus
- chromosome
- nucleoli
- secretory granules
- basement membrane