Slco1a5 Gene Summary [Mouse]
Predicted to enable bile acid transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport; intestinal absorption; and sodium-independent organic anion transport. Predicted to be located in basal plasma membrane and brush border membrane. Predicted to be active in basolateral plasma membrane. Is expressed in ear; nervous system; and thyroid gland. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Slco1a5 |
| Official Name | solute carrier organic anion transporter family, member 1a5 [Source:MGI Symbol;Acc:MGI:1351865] |
| Ensembl ID | ENSMUSG00000063975 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family, member 1a5 |
| Synonyms | OATP-3, Slc21a7, Slco1a2, solute carrier organic anion transporter family, member 1A5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slco1a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- monocarboxylic acid transporter
- bile acid transporter
- thyroid hormone transporter
- KAZAL_FS
- organic anion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proximal tubular toxicity
regulated by
- beta-estradiol
- growth hormone
regulates
- bile acid
- bile salt
- thyroid hormone
- taurocholic acid
- monocarboxylic acid
- organic anion
role in cell
- number
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical cell surfaces
- apical membrane
- basal membrane
- brush border