Ccr1l1 Gene Summary [Mouse]
Predicted to enable C-C chemokine binding activity; C-C chemokine receptor activity; and phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Predicted to be involved in several processes, including monocyte chemotaxis; positive regulation of ERK1 and ERK2 cascade; and positive regulation of monocyte chemotaxis. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr1l1 |
| Official Name | chemokine (C-C motif) receptor 1-like 1 [Source:MGI Symbol;Acc:MGI:104617] |
| Ensembl ID | ENSMUSG00000064039 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor 1-like 1 |
| Synonyms | C-C motif chemokine receptor 1 like 1, Ccr1b, chemokine (C-C motif) receptor 1-like 1, Cmkbr1l1, Mip-1 α R like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccr1l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- C-C chemokine binding
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- plasma membrane extracellular face