Nqo1 Gene Summary [Mouse]
Enables NAD(P)H dehydrogenase (quinone) activity and NADH:ubiquinone reductase (non-electrogenic) activity. Involved in several processes, including protein polyubiquitination; response to lipopolysaccharide; and vitamin K metabolic process. Acts upstream of or within negative regulation of catalytic activity; response to caloric restriction; and response to oxidative stress. Is active in cytoplasm and nucleus. Is expressed in heart; liver; main olfactory bulb; olfactory epithelium; and skin. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hypertension; lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nqo1 |
| Official Name | NAD(P)H dehydrogenase, quinone 1 [Source:MGI Symbol;Acc:MGI:103187] |
| Ensembl ID | ENSMUSG00000003849 |
| Bio databases IDs | |
| Aliases | NAD(P)H dehydrogenase, quinone 1 |
| Synonyms | DHQU, DIA4, DTD, DT-diaphorase, NAD DT-diaphorase, Nadph dehydrogenase, NAD(P)H dehydrogenase, quinone 1, Nadph diaphorase, NAD(P)H quinone dehydrogenase 1, NAD(P)H:quinone oxidoreductase, Nadph Quinone Oxidoreductase-1, NMO1, NMOR, NMOR1, NMORI, Nqo, Ox-1, Qr, QR1, Quinone reductase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nqo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- superoxide dismutase
- NADH dehydrogenase (quinone)
- NAD(P)H2 dehydrogenase (quinone)
- cytochrome-b5 reductase
- enzyme
- protein binding
- identical protein binding
- hsp70 binding domain
- Flavodoxin-like fold
- NADPH-dependent FMN reductase
Pathways
Biological processes and signaling networks where the Nqo1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- acute lymphoblastic lymphoma
- leukemia
- neoplasia
- metastasis
- epithelial neoplasia
- epithelial cancer
- cancer
- non-insulin-dependent diabetes mellitus
- liver neoplasia
role in cell
- cell death
- phosphorylation in
- cellular infiltration by
- production in
- apoptosis
- proliferation
- expression in
- number
- quantity
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nqo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- negative regulation of protein catabolic process
- ubiquinone metabolic process
- response to toxin
- positive regulation of neuron apoptotic process
- response to oxidative stress
- response to ethanol
- response to ischemia
- vitamin E metabolic process
- cellular response to hydrogen peroxide
- response to testosterone stimulus
- response to electrical stimulus
- protein catabolic process
- response to amine stimulus
- protein polyubiquitination
- response to carbohydrate stimulus
- response to nutrient
- cell redox homeostasis
- response to alkaloid
- NADH oxidation
- response to hormone stimulus
- negative regulation of apoptotic process
- innate immune response
- removal of superoxide radicals
- xenobiotic metabolic process
- vitamin K metabolic process
- response to estradiol stimulus
- cellular response to metal ion
- NADPH oxidation
- cellular response to oxidative stress
- response to lipopolysaccharide
- nitric oxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cytoplasm
- cytosol
- neuronal cell body
- synapse
Molecular Function
What the gene product does at the molecular level
- cytochrome-b5 reductase activity
- identical protein binding
- NADH dehydrogenase (quinone) activity
- RNA binding
- protein binding
- NAD(P)H dehydrogenase (quinone) activity
- NADPH dehydrogenase (quinone) activity
- superoxide dismutase activity