Runx1t1 Gene Summary [Mouse]
Enables identical protein binding activity. Involved in negative regulation of fat cell differentiation. Acts upstream of or within fat cell differentiation and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human RUNX1T1 (RUNX1 partner transcriptional co-repressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Runx1t1 |
| Official Name | RUNX1 translocation partner 1 [Source:MGI Symbol;Acc:MGI:104793] |
| Ensembl ID | ENSMUSG00000006586 |
| Bio databases IDs | |
| Aliases | RUNX1 translocation partner 1 |
| Synonyms | AML1-MTG8, AML1T1, CBFA2T1, Cbfa2t1h, CDR, ETO, MTG8, Run1tl, RUNX1 partner transcriptional co-repressor 1, RUNX1 translocation partner 1, ZMYND2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Runx1t1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nhr2 domain
- transcription regulator
- amphipathic helix
- Nhr3 domain
- MYND finger
- transcription co-repressor
- Pst domain
- nervy homology region domain
- transcription factor binding
- coiled-coil domain
- protein binding
- identical protein binding
- YSPTSPS repeat
- Nhr1 domain
- NHR2 domain like
- transcription repression domain
- NHR1 homology to TAF
- transcription activating factor 110 domain
- TAF homology
- zinc finger domain
Pathways
Biological processes and signaling networks where the Runx1t1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- precursor B-cell acute lymphoblastic leukemia
- metastatic breast cancer
- acute lymphoblastic leukemia
- androgenic alopecia
- breast cancer metastatic to brain
- brain metastasis
- clear cell ovarian cancer
- myeloproliferative disorder
role in cell
- apoptosis
- expression in
- differentiation
- proliferation
- cell death
- growth
- recruitment in
- colony formation
- killing
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear matrix fraction
- Cytoplasm
- centrosome
- Golgi Apparatus
- granules
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear speckles
- nuclear matrix
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Runx1t1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- transcription, DNA-dependent
- negative regulation of fat cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- transcription corepressor activity