Arrb2 Gene Summary [Mouse]
Enables protein kinase B binding activity. Involved in several processes, including adult walking behavior; negative regulation of cytokine production; and positive regulation of cell communication. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway and regulation of protein phosphorylation. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in glioblastoma; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human ARRB2 (arrestin beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Arrb2 |
| Official Name | arrestin, beta 2 [Source:MGI Symbol;Acc:MGI:99474] |
| Ensembl ID | ENSMUSG00000060216 |
| Bio databases IDs | |
| Aliases | arrestin, beta 2 |
| Synonyms | AI326910, ARB2, ARR2, Arr3, Arrestin 2, Arrestin-3, arrestin beta 2, arrestin, beta 2, Arrestin β 2, arrestin, β 2, AW122872, BARR2, BARRES, beta-Arrestin 2, β-Arrestin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arrb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- clathrin binding domain
- protein kinase binding
- G-protein-coupled receptor binding
- enzyme binding
- protein domain specific binding
- Arrestin (or S-antigen), N-terminal domain
- protein binding
- receptor binding
- identical protein binding
- docking domain
- Arrestin (or S-antigen), C-terminal domain
- binding protein
- Ap-2 binding domain
Pathways
Biological processes and signaling networks where the Arrb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- COVID-19
- heart failure
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
regulated by
- platelet activating factor
- carbamylcholine
- lipopolysaccharide
- norepinephrine
- [Leu27]IGF-II
- beta-estradiol
- ethanol
- CXCL11
- AGTR1
- 1-(4-ethoxyphenyl)-5-methoxy-2-methylindole-3-carboxylic acid
role in cell
- number
- formation
- formation in
- apoptosis
- survival
- cell death
- internalization by
- expression in
- phosphorylation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endocytic vesicle membrane
- intracellular space
- perinuclear region
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- centrosome
- cytosol
- postsynaptic membrane
- basolateral membrane
- Golgi membrane
- nucleoplasm
- dendritic spines
- cytoplasmic vesicles
- endocytotic vesicle
- pseudopodia
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arrb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- negative regulation of interleukin-1 beta production
- transforming growth factor beta receptor signaling pathway
- dopamine receptor signaling pathway
- transcription from RNA polymerase II promoter
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- cell chemotaxis
- adult walking behavior
- negative regulation of protein ubiquitination
- negative regulation of tumor necrosis factor production
- positive regulation of synaptic transmission, dopaminergic
- regulation of excitatory postsynaptic membrane potential
- negative regulation of NF-kappaB transcription factor activity
- positive regulation of receptor internalization
- negative regulation of toll-like receptor signaling pathway
- G-protein coupled receptor internalization
- negative regulation of natural killer cell mediated cytotoxicity
- positive regulation of cardiac muscle cell differentiation
- negative regulation of interleukin-6 production
- proteasomal ubiquitin-dependent protein catabolic process
- desensitization of G-protein coupled receptor protein signaling pathway
- negative regulation of protein phosphorylation
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- negative regulation of interleukin-12 production
- receptor internalization
- positive regulation of protein kinase B signaling cascade
- protein ubiquitination
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- nucleus
- cytoplasm
- coated pit
- cytosol
- cytoplasmic vesicle
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- D1 dopamine receptor binding
- angiotensin receptor binding
- protein binding
- ubiquitin protein ligase binding
- protein kinase B binding
- receptor binding
- binding, bridging
- enzyme binding