Cyp2b19 Gene Summary [Mouse]

Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including epoxygenase P450 pathway; steroid metabolic process; and xenobiotic catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skin. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Cyp2b19
Official Name
cytochrome P450, family 2, subfamily b, polypeptide 19 [Source:MGI Symbol;Acc:MGI:107303]
Ensembl ID
ENSMUSG00000066704
Bio databases IDs NCBI: 13090 Ensembl: ENSMUSG00000066704
Aliases cytochrome P450, family 2, subfamily b, polypeptide 19
Synonyms Cyp2b12, Cyp2b14, CYP2B15, Cyp2b31, CYPIIB19, cytochrome P450, family 2, subfamily b, polypeptide 12, cytochrome P450, family 2, subfamily b, polypeptide 14, cytochrome P450, family 2, subfamily b, polypeptide 15, cytochrome P450, family 2, subfamily b, polypeptide 19, LOC100360055, LOC100910127, LOC687222, LOC688357
Species
Mouse, Mus musculus
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp2b19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cytochrome P450 (CYP) superfamily
  • Cytochrome P450
  • testosterone 16-alpha-hydroxylase
  • reduced flavin or flavoprotein:oxygen oxidoreductase
  • monooxygenase
  • enzyme
  • steroid hydroxylase
  • heme binding
  • arachidonic acid epoxygenase
  • NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase

Pathways

Biological processes and signaling networks where the Cyp2b19 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • Ca2+
  • dexamethasone
  • indole-3-carbinol
  • omeprazole
  • dipyrone
  • methylprednisolone
  • flutamide
  • L-742694
  • CREB3L3
  • phenobarbital
regulates
  • arachidonic acid
  • 12(R)-hydroxyeicosatetraenoic acid
  • 14(S),15(R)-epoxy-(5Z,8Z,11Z)-eicosatrienoic acid
  • 11(S)-hydroxy-eicosatetraenoic acid
  • 11(S),12(R)-epoxyeicosatrienoic acid
  • 15(R)-hydroxyeicosatetraenoic acid

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Endoplasmic Reticulum
  • endoplasmic reticulum membrane

Gene-Specific Assays for Results You Can Trust

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