Creb3l3

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in positive regulation of transcription by RNA polymerase II and response to endoplasmic reticulum stress. Located in membrane and nucleus. Is expressed in several structures, including extraembryonic visceral endoderm; genitourinary system; gut; liver; and septum transversum. Orthologous to human CREB3L3 (cAMP responsive element binding protein 3 like 3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Creb3l3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Creb3l3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Creb3l3 gene, providing context for its role in the cell.