Hsf5 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity and DNA-binding transcription repressor activity. Involved in male meiotic nuclear division and spermatogenesis. Located in XY body and nucleus. Orthologous to human HSF5 (heat shock transcription factor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsf5 |
| Official Name | heat shock transcription factor family member 5 [Source:MGI Symbol;Acc:MGI:2685585] |
| Ensembl ID | ENSMUSG00000070345 |
| Bio databases IDs | |
| Aliases | heat shock transcription factor family member 5 |
| Synonyms | Gm739, heat shock transcription factor 5, heat shock transcription factor family member 5, HSTF 5, MLZ-220 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HSF-type DNA-binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- sex chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding