Ccl8 Gene Summary [Mouse]
Predicted to enable chemokine receptor binding activity; phospholipase activator activity; and protein kinase activity. Acts upstream of or within positive regulation of myoblast differentiation and positive regulation of myoblast fusion. Located in extracellular space. Is expressed in ductus deferens; epididymis; esophagus; heart ventricle; and testis. Orthologous to human CCL8 (C-C motif chemokine ligand 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl8 |
| Official Name | chemokine (C-C motif) ligand 8 [Source:MGI Symbol;Acc:MGI:101878] |
| Ensembl ID | ENSMUSG00000009185 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) ligand 8 |
| Synonyms | 1810063B20Rik, C-C motif chemokine ligand 8, chemokine ligand 8, HC14, LOC100048554, MCP-2, Scya8 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccl8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- cytokine
- phospholipase activator
Pathways
Biological processes and signaling networks where the Ccl8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- B cell cancer
- plasma cell neoplasm
- mature B-cell neoplasia
- familial amyloid polyneuropathy type I
- rheumatoid arthritis
- peritoneal fibrosis
- insulin-dependent diabetes mellitus
- age-related hearing loss
- laser induced choroidal neovascularization
regulates
role in cell
- differentiation
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space