Gucy2d Gene Summary [Mouse]
Enables odorant binding activity and olfactory receptor activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of smell; olfactory learning; and positive regulation of cGMP-mediated signaling. Predicted to be located in non-motile cilium. Predicted to be active in plasma membrane. Is expressed in spinal cord. [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gucy2d |
| Official Name | guanylate cyclase 2d [Source:MGI Symbol;Acc:MGI:106030] |
| Ensembl ID | ENSMUSG00000074003 |
| Bio databases IDs | |
| Aliases | guanylate cyclase 2d |
| Synonyms | Gc-d, guanylate cyclase 2d, guanylate cyclase 2E, Gucy2e, Gucy2ep, ONE-GC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gucy2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- natriuretic peptide receptor
- Receptor family ligand binding region
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- enzyme
- protein binding
- Serine/Threonine protein kinases, catalytic domain
- olfactory receptor
- Protein Kinases, catalytic domain
- Type 1 periplasmic binding fold superfamily
- guanylate cyclase
- Class III nucleotidyl cyclases
- Adenylyl- / guanylyl cyclase, catalytic domain
- Tyrosine kinase, catalytic domain
- odorant binding
Pathways
Biological processes and signaling networks where the Gucy2d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Antiproliferative Role of Somatostatin Receptor 2
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Endothelin-1 Signaling
- Gap Junction Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Phototransduction Pathway
- Relaxin Signaling
- Synaptic Long Term Depression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- non-motile cilium
- cellular membrane