Alkbh1 Gene Summary [Mouse]
Enables broad specificity oxidative DNA demethylase activity and chemoattractant activity. Involved in positive regulation of gene expression, epigenetic and regulation of translational initiation by tRNA modification. Acts upstream of or within several processes, including generation of neurons; in utero embryonic development; and negative regulation of neuron apoptotic process. Located in euchromatin. Is expressed in several structures, including branchial arch; central nervous system; hemolymphoid system gland; hindlimb muscle; and limb bud. Orthologous to human ALKBH1 (alkB homolog 1, histone H2A dioxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Alkbh1 |
| Official Name | alkB homolog 1, histone H2A dioxygenase [Source:MGI Symbol;Acc:MGI:2384034] |
| Ensembl ID | ENSMUSG00000079036 |
| Bio databases IDs | |
| Aliases | alkB homolog 1, histone H2A dioxygenase |
| Synonyms | neural regeneration protein |
| Species | Mouse, Mus musculus |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
phenotypes
- abnormal kidney morphology
- abnormal spleen morphology
- hypoactivity
- improved glucose tolerance
- preweaning lethality complete penetrance
- abnormal cell physiology
- abnormal eye morphology
- abnormal frontal bone morphology
- abnormal glucose tolerance
- abnormal interparietal bone morphology
- abnormal lens fiber morphology
- abnormal lens morphology
- abnormal mandible morphology
- abnormal metatarsal bone morphology
- abnormal neural tube closure
- abnormal parietal bone morphology
- abnormal phalanx morphology
- abnormal placenta junctional zone morphology
- abnormal seminiferous tubule morphology
- abnormal sternum morphology
- abnormal sternum ossification
- abnormal survival
- abnormal tooth development
- absent nasal bone
- acoria
- anophthalmia
- aphakia
- broad snout
- decreased birth weight
- decreased bone ossification
- decreased fetal size
- decreased litter size
- decreased male germ cell number
- decreased placenta weight
- decreased placental labyrinth size
- decreased spongiotrophoblast cell number
- decreased survivor rate
- decreased testis weight
- decreased trophoblast giant cell number
- decreased trophoblast glycogen cell number
- delayed cranial suture closure
- delayed intramembranous bone ossification
- disorganized retinal layers
- ectopia lentis
- exencephaly
- fetal growth retardation
- intracranial hemorrhage
- microphthalmia
- pale placenta
- postnatal growth retardation
- retinal degeneration
- seminiferous tubule degeneration
- short frontal bone
- short nasal bone
- short snout
- small testis
- wide cranial sutures
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown