Tardbp Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and pre-mRNA intronic binding activity. Involved in positive regulation of protein import into nucleus; regulation of circadian rhythm; and regulation of protein stability. Acts upstream of or within RNA splicing. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and heart. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; amyotrophic lateral sclerosis type 10; and frontotemporal dementia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tardbp |
| Official Name | TAR DNA binding protein [Source:MGI Symbol;Acc:MGI:2387629] |
| Ensembl ID | ENSMUSG00000041459 |
| Bio databases IDs | |
| Aliases | TAR DNA binding protein |
| Synonyms | 1190002A23Rik, AF311304, ALS10, Tadbp, TAR DNA binding protein, TAR DNA-binding protein-43, TDP-43 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tardbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine rich domain
- RNA recognition motif (RRM) superfamily
- transcription regulator
- lipid binding
- RNA recognition motif
- nucleic acid binding
- protein binding activity, bridging
- caspase cleavage site
- nuclear localization sequence
- protein binding
- ubiquitin-like domain
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA binding
- beta strand or sheet
- mRNA 3' UTR binding
- N-terminal domain of transactive response DNA-binding protein 43
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the Tardbp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
- paralysis
- weight loss
- gait disturbance
- motor dysfunction
- amyotrophic lateral sclerosis 10
- familial amyotrophic lateral sclerosis
- TARDBP -related frontotemporal dementia with TDP43 inclusions
- mild cognitive impairment
- Alexander disease
phenotypes
- abnormal startle reflex
- decreased basophil cell number
- decreased blood urea nitrogen level
- decreased mean platelet volume
- decreased neutrophil cell number
- embryonic lethality prior to organogenesis
- increased fasting circulating glucose level
- increased lymphocyte cell number
- preweaning lethality complete penetrance
- abnormal GABAergic neuron morphology
- abnormal basophil cell number
- abnormal blood urea nitrogen level
- abnormal brain interneuron morphology
- abnormal cognition
- abnormal eating behavior
- abnormal fasting circulating glucose level
- abnormal learning/memory/conditioning
- abnormal locomotor behavior
- abnormal motor capabilities/coordination/movement
- abnormal motor neuron innervation pattern
- abnormal motor neuron morphology
- abnormal muscle tone
- abnormal neuromuscular synapse morphology
- abnormal object recognition memory
- abnormal platelet volume
- absent inner cell mass proliferation
- astrocytosis
- cognitive inflexibility
- decreased grip strength
- decreased motor neuron number
- decreased stereotypic behavior
- embryonic lethality between implantation and somite formation complete penetrance
- embryonic lethality complete penetrance
- hindlimb paralysis
- impaired coordination
- impaired muscle relaxation
- increased body weight
- increased vertical activity
- kyphosis
- limb grasping
- microgliosis
- motor neuron degeneration
- neuronal cytoplasmic inclusions
- polyphagia
- postnatal lethality complete penetrance
- premature death
- prenatal lethality complete penetrance
- prenatal lethality incomplete penetrance
- preweaning lethality incomplete penetrance
- skeletal muscle atrophy
- slow postnatal weight gain
- spasticity
- tremors
- weight loss
role in cell
- activation
- production in
- proliferation
- loss
- cytotoxicity
- number
- expression in
- upregulation in
- quantity
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear chromatin
- organelle
- Cytoplasm
- vesicles
- Mitochondria
- granules
- cytosol
- interchromatin granules
- nucleoplasm
- nucleoli
- nuclear rim
- nuclear speckles
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tardbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation by host of viral transcription
- 3'-UTR-mediated mRNA stabilization
- positive regulation of protein import into nucleus
- RNA splicing
- 3'-UTR-mediated mRNA destabilization
- regulation of apoptotic process
- mRNA processing
- regulation of circadian rhythm
- negative regulation of gene expression
- regulation of protein stability
- rhythmic process
- negative regulation of protein phosphorylation
- nuclear inner membrane organization
- regulation of gene expression
- positive regulation of insulin secretion
- regulation of cell cycle
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- perichromatin fibrils
- nuclear speck
- mitochondrion
- intracellular non-membrane-bounded organelle
- interchromatin granule
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- pre-mRNA intronic binding
- identical protein binding
- protein binding
- RNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- lipid binding
- mRNA 3'-UTR binding