Fpr3 Gene Summary [Mouse]
Enables signaling receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to several human genes including FPR2 (formyl peptide receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fpr3 |
| Official Name | formyl peptide receptor 3 [Source:MGI Symbol;Acc:MGI:1194495] |
| Ensembl ID | ENSMUSG00000079700 |
| Bio databases IDs | |
| Aliases | formyl peptide receptor 3 |
| Synonyms | ALX, Ccr12, formyl peptide receptor 3, Fprl1, Fpr-rs1, Fpr-s1, LXA4-R, RGD1566044 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fpr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- scavenger receptor binding
- 7 transmembrane receptor (rhodopsin family)
- receptor binding
- beta-amyloid binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Fpr3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- lipoxin A4
regulated by
- lipopolysaccharide
- E. coli B4 lipopolysaccharide
- 4-fluoro-benzoic acid [5-(3-trifluoromethyl-phenyl)-2-furyl]-methylene-hydrazide
- neutrophils
- nicotinic acid [5-(3-bromophenyl)-2-furyl]methylene-hydrazide
- GATA2
- Trp-Arg-Trp-Trp-Trp-Trp-NH2
- N-t-Boc-Phe-D-Leu-Phe-D-Leu-Phe
regulates
- guanosine triphosphate
- 1,4,5-IP3
- IL10
role in cell
- migration
- loss
- cell rolling
- aggregation
- adhesion
- loss in
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane