Slfn14 Gene Summary [Mouse]
Enables RNA endonuclease activity and ribosome binding activity. Involved in mRNA catabolic process and rRNA catabolic process. Located in nucleus. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 20. Orthologous to human SLFN14 (schlafen family member 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slfn14 |
| Official Name | schlafen 14 [Source:MGI Symbol;Acc:MGI:2684866] |
| Ensembl ID | ENSMUSG00000082101 |
| Bio databases IDs | |
| Aliases | schlafen 14 |
| Synonyms | BDPLT20, Gm20, LOC100912082, LOC103689937, LRRGT00163, LT629148.8, LT629154.14, schlafen 14, schlafen family member 14, Slfn14-ps |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slfn14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative DNA-binding domain
- ribosome binding
- endoribonuclease
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slfn14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to magnesium ion
- cellular response to manganese ion
- rRNA catabolic process
- mRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ribosome binding
- endoribonuclease activity