SLFN14 Gene Summary [Human]
The protein encoded by this gene plays an important role in platelet formation and function. Defects in this gene are a cause of thrombocytopenia with excessive bleeding. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | SLFN14 |
| Official Name | schlafen family member 14 [Source:HGNC Symbol;Acc:HGNC:32689] |
| Ensembl ID | ENSG00000236320 |
| Bio databases IDs | |
| Aliases | schlafen family member 14 |
| Synonyms | BDPLT20, Gm20, LOC100912082, LOC103689937, LRRGT00163, LT629148.8, LT629154.14, schlafen 14, schlafen family member 14, Slfn14-ps |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLFN14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative DNA-binding domain
- ribosome binding
- endoribonuclease
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLFN14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to magnesium ion
- cellular response to manganese ion
- rRNA catabolic process
- mRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ribosome binding
- endoribonuclease activity