Eif4a3l1

Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be involved in several processes, including embryonic cranial skeleton morphogenesis; negative regulation of excitatory postsynaptic potential; and regulation of gene expression. Predicted to be located in several cellular components, including dendrite; neuronal cell body; and nucleoplasm. Predicted to be part of U2-type catalytic step 1 spliceosome; catalytic step 2 spliceosome; and exon-exon junction complex. Predicted to be active in glutamatergic synapse and nucleolus. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif4a3l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.