Irf1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including defense response to other organism; regulation of T cell activation; and regulation of gene expression. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation; positive regulation of interleukin-12 production; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including bone marrow; early conceptus; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 117; lung cancer (multiple); smallpox; and stomach cancer (multiple). Orthologous to human IRF1 (interferon regulatory factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irf1 |
| Official Name | interferon regulatory factor 1 [Source:MGI Symbol;Acc:MGI:96590] |
| Ensembl ID | ENSMUSG00000018899 |
| Bio databases IDs | |
| Aliases | interferon regulatory factor 1 |
| Synonyms | IFN REGULATORY FACTOR 1, IMD117, interferon regulatory factor 1, ISGF2, LSIR, MAR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- IRF
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- acidic domain
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- basic domain
- transcription factor activity
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Irf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- IL-12 Signaling and Production in Macrophages
- IL-15 Production
- iNOS Signaling
- Interferon Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Prolactin Signaling
- Retinoic acid Mediated Apoptosis Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- experimental autoimmune encephalomyelitis
- neoplasia
- diabetic nephropathy
- cardiac hypertrophy
- cardiac fibrosis
- renal fibrosis
- asthma
- metastasis
role in cell
- expression in
- binding in
- cell viability
- growth
- differentiation
- apoptosis
- replication in
- binding
- activation in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Irf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interferon-gamma-mediated signaling pathway
- positive regulation of type I interferon production
- negative regulation of cell proliferation
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- immune system process
- regulation of transcription from RNA polymerase II promoter
- cellular response to mechanical stimulus
- positive regulation of interleukin-12 production
- negative regulation of regulatory T cell differentiation
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of interferon-beta production
- CD8-positive, alpha-beta T cell differentiation
- apoptotic process
- regulation of innate immune response
- defense response to virus
- regulation of cell cycle
- regulation of MyD88-dependent toll-like receptor signaling pathway
- regulation of adaptive immune response
- regulation of CD8-positive, alpha-beta T cell proliferation
- cellular response to interferon-beta
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity