Tox3 Gene Summary [Mouse]
Predicted to enable chromatin DNA binding activity; phosphoprotein binding activity; and protein homodimerization activity. Predicted to be involved in calcium-mediated signaling; negative regulation of neuron apoptotic process; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and sensory organ. Orthologous to human TOX3 (TOX high mobility group box family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tox3 |
| Official Name | TOX high mobility group box family member 3 [Source:MGI Symbol;Acc:MGI:3039593] |
| Ensembl ID | ENSMUSG00000043668 |
| Bio databases IDs | |
| Aliases | TOX high mobility group box family member 3 |
| Synonyms | 500-9, C230068E13, CAGF9, TNRC9, TOX high mobility group box family member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tox3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- phosphoprotein binding
- protein homodimerization
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- cancer
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- breast carcinoma
- insomnia
- Parkinson disease
- herpes zoster
- restless legs syndrome
role in cell
- expression in
- apoptosis
- cell death
- binding in
- trimethylation in
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tox3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- regulation of apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- protein homodimerization activity
- transcription coactivator activity
- phosphoprotein binding
- chromatin binding