Usp3 Gene Summary [Mouse]
The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. In addition, knock down of protein levels results in spontaneous tumor development and shortened lifespan, consistent with a function in preserving chromosomal integrity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | Usp3 |
| Official Name | ubiquitin specific peptidase 3 [Source:MGI Symbol;Acc:MGI:2152450] |
| Ensembl ID | ENSMUSG00000032376 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 3 |
| Synonyms | AA409661, SIH003, ubiquitin specific peptidase 3, UBP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- nucleic acid binding
- peptidase
- chromatin binding
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- enzyme
- sequence-specific DNA binding
- Peptidase_C19
- Zn-finger in ubiquitin-hydrolases and other protein
- double-stranded DNA binding
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- atrial fibrillation
- pervasive developmental disorder
- major depression
- metastasis
- albuminuria
role in cell
- expression in
- proliferation
- accumulation in
- differentiation
- epithelial-mesenchymal transition
- growth
- migration
- sphere formation
- invasion by
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- Flemming body
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- DNA repair
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- zinc ion binding
- histone binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding