Slc25a16 Gene Summary [Rat]
Predicted to enable several functions, including 5'-flap endonuclease activity; ATP hydrolysis activity; and DNA helicase activity. Predicted to be involved in DNA metabolic process; DNA replication checkpoint signaling; and mitochondrial coenzyme A transmembrane transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC25A16 (solute carrier family 25 member 16). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a16 |
| Official Name | solute carrier family 25 member 16 [Source:RGD Symbol;Acc:1311311] |
| Ensembl ID | ENSRNOG00000000387 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 member 16 |
| Synonyms | 3110021G18RIK, D10S105E, GDA, GDC, hGP, HGT.1, hML7, ML7, solute carrier family 25 member 16, solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc25a16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- porter
- nuclease
- Mitochondrial carrier protein
- coenzyme A transporter
- flap endonuclease
- ATPase
- DNA binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive isolated fingernail dysplasia
- bipolar disorder
- cortical visual impairment and intellectual disability
- drug dependence
- nonsyndromic congenital nail disorder
regulated by
- dihydrotestosterone
- keratinocytes
regulates
- D-pantothenic acid
- coenzyme A
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc25a16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial transport
- pantothenate metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- antiporter activity
- coenzyme A transmembrane transporter activity