Syp Gene Summary [Rat]
Enables protein domain specific binding activity and syntaxin-1 binding activity. Involved in endocytosis; regulation of opioid receptor signaling pathway; and response to amyloid-beta. Located in several cellular components, including postsynaptic density; presynaptic active zone; and synaptic vesicle. Part of protein-containing complex. Is active in synaptic vesicle membrane. Biomarker of Alzheimer's disease and alcohol use disorder. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to human SYP (synaptophysin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syp |
| Official Name | synaptophysin [Source:RGD Symbol;Acc:3802] |
| Ensembl ID | ENSRNOG00000059720 |
| Bio databases IDs | |
| Aliases | synaptophysin |
| Synonyms | A230093K24RIK, MRX96, MRXSYP, p38, Syn, synaptophysin, Synaptophysin1, Syp1, XLID96 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Syp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- SNARE binding
- cholesterol binding
- binding protein
- SH2-domain binding
- syntaxin-1 binding
- protein domain specific binding
- protein binding
- cytosolic tail domain
- identical protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- schizophrenia
- epithelial cancer
- Alzheimer disease
- neuroendocrine carcinoma
- neuroendocrine cancer
- x-linked mental retardation type 96
- obesity
- Merkel-cell carcinoma
- Merkel cell cancer
role in cell
- formation
- endocytosis
- priming
- endocytosis by
- paired-pulse facilitation
- recovery in
- synaptic transmission in
- plasticity
- long-term potentiation
- recycling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- synaptic plasma membrane fractions
- soluble fraction
- postsynaptic density (PSD) fractions
- membrane fraction
- synaptosomal membrane fractions
- synaptic vesicle membrane
- proximal axon
- presynaptic regions
- cell surface
- cell periphery
- basal compartment
- perinuclear region
- intracellular membranes
- cellular membrane
- vacuole
- Plasma Membrane
- vesicles
- granules
- cytosol
- presynaptic membrane
- synaptic membrane
- dendritic spines
- synaptic vesicles
- neuromuscular junctions
- neurites
- nerve ending
- synaptosomes
- synapse
- photoreceptor outer segments
- early endosomes
- transport vesicles
- dense-core vesicles
- endocytotic vesicle
- synaptic-like microvesicles
- membrane rafts
- cellular protrusions
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- presynaptic terminals
- neuromuscular synapse
- excitatory synapses
- clathrin-coated vesicles
- mossy fibers
- vesicle fraction
- synaptic vesicle fractions
- synaptosomal fractions
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Syp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic vesicle endocytosis
- synaptic vesicle membrane organization
- regulation of long-term neuronal synaptic plasticity
- regulation of neuronal synaptic plasticity
- regulation of synaptic vesicle exocytosis
- synaptic vesicle maturation
- endocytosis
- regulation of short-term neuronal synaptic plasticity
- regulation of opioid receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- perinuclear region of cytoplasm
- presynaptic active zone
- terminal button
- synaptic vesicle
- excitatory synapse
- neuromuscular junction
- synaptic vesicle membrane
- neuron projection
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cholesterol binding
- SH2 domain binding