Pms2 Gene Summary [Rat]
Predicted to enable ATP hydrolysis activity and single base insertion or deletion binding activity. Predicted to contribute to MutSalpha complex binding activity and single-stranded DNA binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal cancer type 4; mismatch repair cancer syndrome; ovarian cancer; and urinary bladder cancer. Orthologous to human PMS2 (PMS1 homolog 2, mismatch repair system component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pms2 |
| Official Name | PMS1 homolog 2, mismatch repair system component [Source:RGD Symbol;Acc:1305483] |
| Ensembl ID | ENSRNOG00000001040 |
| Bio databases IDs | |
| Aliases | PMS1 homolog 2, mismatch repair system component |
| Synonyms | HNPCC4, LYNCH4, MLH4, MMRCS4, PMS1 homolog 2, mismatch repair system component, PMS2CL, PMSL2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pms2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MutL C terminal dimerisation domain
- Histidine kinase-like ATPase domain
- DNA mismatch repair protein, C-terminal domain
- TopoII_MutL_Trans
- enzyme
- protein binding
- DNA binding
- endonuclease
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- binding protein
- MutL C terminal dimerization domain
- single-stranded DNA binding
- double-stranded DNA binding
- DNA mismatch repair protein MutL
- Histidine kinase-like ATPases
Pathways
Biological processes and signaling networks where the Pms2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- breast cancer
- esophageal squamous cell carcinoma
- endometrial cancer
- prostate cancer
- ovarian cancer
- biliary tract cancer
- Lynch syndrome
role in cell
- apoptosis
- breakdown
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pms2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of isotype switching to IgA isotypes
- somatic recombination of immunoglobulin gene segments
- positive regulation of isotype switching to IgG isotypes
- mismatch repair
- response to xenobiotic stimulus
- somatic hypermutation of immunoglobulin genes
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- MutLalpha complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- MutSalpha complex binding
- ATPase activity
- DNA binding
- ATP binding
- protein binding
- endonuclease activity
- single base insertion or deletion binding
- single-stranded DNA binding