Rasa1 Gene Summary [Rat]
Enables several functions, including GTPase activator activity; platelet-derived growth factor receptor binding activity; and protein kinase binding activity. Involved in several processes, including activation of GTPase activity; cellular response to epidermal growth factor stimulus; and cellular response to platelet-derived growth factor stimulus. Located in nuclear membrane. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Orthologous to human RASA1 (RAS p21 protein activator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rasa1 |
| Official Name | RAS p21 protein activator 1 [Source:RGD Symbol;Acc:3537] |
| Ensembl ID | ENSRNOG00000029185 |
| Bio databases IDs | |
| Aliases | RAS p21 protein activator 1 |
| Synonyms | CM-AVM, CMAVM1, GAP, GAPX, p120, p120GAP, P120RASGAP, PKWS, RASA, RASGAP, RAS p21 protein activator 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rasa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase activator
- Ras GTPase Activating Domain
- GTPase-activator protein for Ras-like GTPases
- receptor tyrosine kinase binding
- GTPase-activator protein for Ras-like GTPase
- ion channel binding
- phosphatase
- PH domain
- Src homology 2 (SH2) domain
- C2 domain
- protein kinase binding
- catalytic domain
- platelet-derived growth factor receptor binding
- enzyme binding
- GTPase activating domain
- GTPase
- phosphotyrosine binding
- protein binding
- receptor binding
- Pleckstrin homology-like domain
- proline tyrosine motif
- Src Homology 3 domain superfamily
- binding protein
- kinase binding
- Protein kinase C conserved region 2 (CalB)
- transporter
Pathways
Biological processes and signaling networks where the Rasa1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Axonal Guidance Signaling
- Cdc42 Signaling
- EGF Signaling
- Ephrin A Signaling
- Ephrin Receptor Signaling
- G-Protein Coupled Receptor Signaling
- GDNF Family Ligand-Receptor Interactions
- Gα12/13 Signaling
- Huntington's Disease Signaling
- IGF-1 Signaling
- Molecular Mechanisms of Cancer
- PDGF Signaling
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- non-insulin-dependent diabetes mellitus
- neoplasia
- hyperplasia
- prostate cancer
- epithelial cancer
- cancer
- liver cancer
- liver neoplasia
- digestive system cancer
role in cell
- expression in
- apoptosis
- accumulation
- activation in
- loss
- cell death
- morphology
- proliferation
- phosphorylation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- intracellular compartment
- intracellular space
- Plasma Membrane
- cytosol
- nuclear envelope
- cell membrane leading edge
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rasa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- signal transduction
- negative regulation of cell adhesion
- blood vessel morphogenesis
- vasculogenesis
- negative regulation of neuron apoptotic process
- regulation of actin filament polymerization
- negative regulation of cell-matrix adhesion
- negative regulation of apoptotic process
- cytokinesis after mitosis
- ephrin receptor signaling pathway
- regulation of RNA metabolic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- ruffle
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- potassium channel inhibitor activity
- GTPase binding
- GTPase activity
- GTPase activator activity
- receptor binding