Fan1 Gene Summary [Rat]
Predicted to enable flap-structured DNA binding activity; nuclease activity; and ubiquitin-modified protein reader activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and nucleotide-excision repair. Predicted to be located in several cellular components, including cilium; intercellular bridge; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fan1 |
| Official Name | FANCD2 and FANCI associated nuclease 1 [Source:RGD Symbol;Acc:1566323] |
| Ensembl ID | ENSRNOG00000023985 |
| Bio databases IDs | |
| Aliases | FANCD2 and FANCI associated nuclease 1 |
| Synonyms | 6030441H18Rik, FANCD2 and FANCI associated nuclease 1, FANCD2/FANCI-associated nuclease 1, hFAN1, KIAA1018, KMIN, mFAN1, MTMR15, RGD1566323 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fan1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBZ domain
- 5'-3' exonuclease
- Rad18-like CCHC zinc finger
- protein binding activity, bridging
- VRR-NUC domain
- enzyme
- flap endonuclease
- protein binding
- PDDEXK family nucleases
- magnesium ion binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- karyomegalic interstitial nephritis
- Huntington disease
- hypertriglyceridemia
- Lynch syndrome
regulated by
- FAN1
- ficusin
role in cell
- recruitment in
- number
- survival
- function
- polyploidization
- lipotoxicity in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cilia
- cytoplasmic bridges
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fan1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- double-strand break repair via homologous recombination
- nucleotide-excision repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 5'-3' exonuclease activity
- magnesium ion binding
- 5'-flap endonuclease activity
- protein binding
- phosphodiesterase I activity
- flap-structured DNA binding