Stard13 Gene Summary [Rat]
Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Predicted to act upstream of or within several processes, including endothelial tube lumen extension; negative regulation of cell migration involved in sprouting angiogenesis; and negative regulation of sprouting angiogenesis. Predicted to be located in membrane. Orthologous to human STARD13 (StAR related lipid transfer domain containing 13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stard13 |
| Official Name | StAR-related lipid transfer domain containing 13 [Source:RGD Symbol;Acc:1564816] |
| Ensembl ID | ENSRNOG00000001090 |
| Bio databases IDs | |
| Aliases | StAR-related lipid transfer domain containing 13 |
| Synonyms | ARHGAP37, DLC2, GT650, LINC00464, RGD1564816, StAR-related lipid transfer domain containing 13 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stard13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- SRPBCC domain
- Sterile alpha motif
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- idiopathic scoliosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- cerebral aneurysm
- alcoholism
- organismal death
- melanoma
- melanoma cancer
- diverticular disease
regulates
role in cell
- proliferation
- morphology
- migration
- transformation
- quantity
- formation
- attachment
- tubulation
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stard13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rho protein signal transduction
- signal transduction
- regulation of small GTPase mediated signal transduction
- endothelial cell migration
- negative regulation of cell migration involved in sprouting angiogenesis
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- lipid particle
- mitochondrial membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- lipid binding