Serpina6 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity and steroid binding activity. Predicted to act upstream of or within glucocorticoid metabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in corticosteroid-binding globulin deficiency. Orthologous to human SERPINA6 (serpin family A member 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpina6 |
| Official Name | serpin family A member 6 [Source:RGD Symbol;Acc:1595901] |
| Ensembl ID | ENSRNOG00000009438 |
| Bio databases IDs | |
| Aliases | serpin family A member 6 |
| Synonyms | CBG, Corticosteroid-binding globulin, serine (or cysteine) peptidase inhibitor, clade A, member 6, serpin family A member 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpina6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- Serpin (serine protease inhibitor)
- steroid binding
Pathways
Biological processes and signaling networks where the Serpina6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fatigue
- osteoporosis
- corticosteroid-binding globulin deficiency
- early onset hypertension
- cholangiocarcinoma
- cholangiocarcinoma cancer
- functional hypothalamic amenorrhea
- femoral fracture
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serpina6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endopeptidase activity
- glucocorticoid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- steroid binding