Sds Gene Summary [Rat]
Enables L-serine ammonia-lyase activity and threonine deaminase activity. Involved in protein-containing complex assembly; response to amino acid; and response to cobalamin. Predicted to be located in cytosol and mitochondrion. Orthologous to human SDS (serine dehydratase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sds |
| Official Name | serine dehydratase [Source:RGD Symbol;Acc:67376] |
| Ensembl ID | ENSRNOG00000001388 |
| Bio databases IDs | |
| Aliases | serine dehydratase |
| Synonyms | 4432411H13Rik, hSDH, RATSDHE1, SDH, SDH2, Sdhe1, serine dehydratase, TDH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sds often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pyridoxal phosphate binding
- Pyridoxal-phosphate dependent enzyme
- threonine ammonia-lyase
- Trp-synth-beta_II
- L-serine ammonia-lyase
- protein homodimerization
- enzyme
- protein binding
- enoyl-CoA hydratase
Pathways
Biological processes and signaling networks where the Sds gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastroesophageal junction adenocarcinoma
- epithelial cancer
- colorectal cancer
- liver cancer
- hepatocellular carcinoma
- esophagogastric junction cancer
- hepatitis B virus-related hepatocellular carcinoma
- insulin resistance
regulates
- L-serine
- D-serine
- protein-protein complex
- pyruvic acid
role in cell
- gluconeogenesis in
- long-term potentiation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sds gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyruvate biosynthetic process
- isoleucine biosynthetic process
- gluconeogenesis
- lipid metabolic process
- threonine catabolic process
- L-serine catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- L-serine ammonia-lyase activity
- pyridoxal phosphate binding
- protein binding
- protein homodimerization activity
- L-threonine ammonia-lyase activity