Poglut1

Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in several processes, including positive regulation of Notch signaling pathway; protein O-linked glycosylation via serine; and regulation of gastrulation. Predicted to act upstream of or within several processes, including paraxial mesoderm development; regulation of Notch signaling pathway; and somitogenesis. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in Dowling-Degos disease and autosomal recessive limb-girdle muscular dystrophy type 2Z. Orthologous to human POGLUT1 (protein O-glucosyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Poglut1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Poglut1 gene, providing context for its role in the cell.