F9 Gene Summary [Rat]
Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation and zymogen activation. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in X-linked thrombophilia due to factor IX defect; X-linked warfarin sensitivity; and hemophilia B. Orthologous to human F9 (coagulation factor IX). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | F9 |
| Official Name | coagulation factor IX [Source:RGD Symbol;Acc:2589] |
| Ensembl ID | ENSRNOG00000003430 |
| Bio databases IDs | |
| Aliases | coagulation factor IX |
| Synonyms | BAX326, Cf-9, coagulation factor IX, coagulation factor IX [recombinant], F9 p22, factor IX concentrate, FIX, HEMB, Nonacog alfa, nonacog gamma, nonacog γ, P19, plasma-derived factor IX, PTC, recombinant coagulation factor IX, recombinant factor IX, rFactor IX, rFIX, rixubis, THPH8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat F9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- calcium-binding EGF-like domain
- Tryp_SPc
- peptidase
- Human growth factor-like EGF
- calcium ion binding
- metal ion binding
- protein binding
- EGF-like domain
- EGF_CA
- protease domain
- endopeptidase
- trypsin
- coagulation factor IXa
- spacer domain
- loop domain
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
- Coagulation Factor Xa inhibitory site
Pathways
Biological processes and signaling networks where the F9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- stroke
- migraines
- myocardial infarction
- epithelial cancer
- cancer
- cardiovascular death
- chronic renal failure
- inhibitor positive hemophilia A
- hemophilia B
role in cell
- proliferation
- binding
- expression in
- cell cycle progression
- transduction
- cell-mediated response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Plasma Membrane
- endoplasmic reticulum lumen
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat F9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- zymogen activation
- proteolysis
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- Golgi lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- calcium ion binding
- serine-type endopeptidase activity
- endopeptidase activity