Mgat2 Gene Summary [Rat]
Enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity and carbohydrate binding activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Predicted to be located in Golgi apparatus and cytoplasmic side of rough endoplasmic reticulum membrane. Predicted to be part of large ribosomal subunit. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Orthologous to human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgat2 |
| Official Name | alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Source:RGD Symbol;Acc:620098] |
| Ensembl ID | ENSRNOG00000004234 |
| Bio databases IDs | |
| Aliases | alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
| Synonyms | AA407964, alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, CDG2A, CDGS2, GLCNACTII, GNT2, GNT-II, mannoside acetylglucosaminyltransferase 2, α-1,6-mannosyl-glycoprotein 2-β-N-acetylglucosaminyltransferase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mgat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetylglucosaminyltransferase II (MGAT2)
- protein homodimerization
- enzyme
- carbohydrate binding
- manganese ion binding
- alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- proteinuria
- congenital disorders of glycosylation type 2a
- kyphoscoliosis
- rectal prolapse
- hematuria
- hypoglycemia
- tremor
- paralysis
- glomerulonephritis
regulates
- asparagine
- triacylglycerol
- diacylglycerol
role in cell
- quantity
- differentiation
- number
- storage in
- dipeptide repeat protein sensitivity
- endoplasmic reticulum stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mgat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
- oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
- Golgi apparatus
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
- manganese ion binding