Xbp1 Gene Summary [Rat]
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including endoplasmic reticulum unfolded protein response; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and serotonin secretion, neurotransmission. Predicted to be located in cytosol and endoplasmic reticulum membrane. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Biomarker of borna disease and metabolic dysfunction-associated steatotic liver disease. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xbp1 |
| Official Name | X-box binding protein 1 [Source:RGD Symbol;Acc:1303073] |
| Ensembl ID | ENSRNOG00000010298 |
| Bio databases IDs | |
| Aliases | X-box binding protein 1 |
| Synonyms | D11Ertd39e, Hepatocarcinogenesis-related transcription factor, HTF, Sxbp-1, Transcription related factor in liver cancer, TREB-5, X-box binding protein 1, XBP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Xbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- transcription activation domain
- chromatin binding
- estrogen receptor binding
- identical protein binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- bZIP
- ubiquitin protein ligase binding
- protein kinase binding
- protease binding
- nucleic acid binding
- enzyme binding
- Basic region leucine zipper
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphoinositide 3-kinase binding
- double-stranded DNA binding
- pXBP1(U) degradation motif
- transcription factor activity
- CAD domain
- protein heterodimerization
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Xbp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- anemia
- dextran sodium sulfate-induced colitis
- hyperglycemia
- hepatic fibrosis
- epithelial cancer
- enteritis
- ovarian neoplasia
- ulcerative colitis
- acute lung injury
regulated by
- ascorbic acid
- hemin
- tretinoin
- bilirubin
- palmitic acid
- lipopolysaccharide
- D-glucose
- glutamine
- IXA4
- tunicamycin
role in cell
- cell viability
- expression in
- growth
- degradation in
- cell death
- number
- recruitment
- differentiation
- survival
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Xbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- protein transport
- transcription from RNA polymerase II promoter
- positive regulation of fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- cholesterol homeostasis
- positive regulation of angiogenesis
- positive regulation of MHC class II biosynthetic process
- sterol homeostasis
- cellular response to insulin stimulus
- cellular response to amino acid stimulus
- immune response
- cellular response to fructose stimulus
- cellular response to glucose stimulus
- endoplasmic reticulum unfolded protein response
- angiogenesis
- liver development
- autophagy
- cellular response to interleukin-4
- cellular response to peptide hormone stimulus
- apoptotic process
- positive regulation of immunoglobulin production
- negative regulation of myotube differentiation
- cellular triglyceride homeostasis
- positive regulation of vascular wound healing
- cellular response to nutrient
- positive regulation of plasma cell differentiation
- fatty acid homeostasis
- neuron development
- positive regulation of endoplasmic reticulum unfolded protein response
- fatty acid biosynthetic process
- cellular response to glucose starvation
- positive regulation of B cell differentiation
- adipose tissue development
- ubiquitin-dependent protein catabolic process
- regulation of transcription from RNA polymerase II promoter
- muscle organ development
- cellular response to lipopolysaccharide
- negative regulation of apoptotic process
- positive regulation of T cell differentiation
- positive regulation of interleukin-6 production
- positive regulation of hepatocyte proliferation
- response to endoplasmic reticulum stress
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity