Cox7a2l Gene Summary [Rat]
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in mitochondrial respirasome assembly. Predicted to be located in nucleolus. Predicted to be part of respiratory chain complex. Predicted to be active in mitochondrial inner membrane. Orthologous to human COX7A2L (cytochrome c oxidase subunit 7A2 like). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox7a2l |
| Official Name | cytochrome c oxidase subunit 7A2 like [Source:RGD Symbol;Acc:1306111] |
| Ensembl ID | ENSRNOG00000004526 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 7A2 like |
| Synonyms | COX7AR, COX7RP, cytochrome c oxidase subunit 7A2 like, Cytochrome c oxidase subunit viia polypeptide 2-like, EB1, LOC105374543, SCAF1, SCAFI, SIG-81, Silg81 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cox7a2l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Cyt_c_Oxidase_VIIa
- protein binding activity, bridging
- enzyme
Pathways
Biological processes and signaling networks where the Cox7a2l gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- Huntington disease
- gastroesophageal reflux
- insulin resistance
role in cell
- apoptosis
- proliferation
- growth
- oxygen consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cox7a2l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of oxidative phosphorylation
- mitochondrial electron transport, cytochrome c to oxygen
- mitochondrial respiratory chain supercomplex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial respiratory chain
- mitochondrion
- nucleolus
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- cytochrome-c oxidase activity