COX7A2L Gene Summary [Human]
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | COX7A2L |
| Official Name | cytochrome c oxidase subunit 7A2 like [Source:HGNC Symbol;Acc:HGNC:2289] |
| Ensembl ID | ENSG00000115944 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 7A2 like |
| Synonyms | COX7AR, COX7RP, cytochrome c oxidase subunit 7A2 like, Cytochrome c oxidase subunit viia polypeptide 2-like, EB1, LOC105374543, SCAF1, SCAFI, SIG-81, Silg81 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COX7A2L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Cyt_c_Oxidase_VIIa
- protein binding activity, bridging
- enzyme
Pathways
Biological processes and signaling networks where the COX7A2L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- Huntington disease
- gastroesophageal reflux
- insulin resistance
role in cell
- apoptosis
- proliferation
- growth
- oxygen consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COX7A2L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of oxidative phosphorylation
- mitochondrial electron transport, cytochrome c to oxygen
- mitochondrial respiratory chain supercomplex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial respiratory chain
- mitochondrion
- nucleolus
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- cytochrome-c oxidase activity