Epha7 Gene Summary [Rat]
Enables ephrin receptor binding activity and protein tyrosine kinase activity. Involved in brain development; phosphorylation; and positive regulation of apoptotic process. Located in dendrite; neuronal cell body; and postsynaptic membrane. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Orthologous to human EPHA7 (EPH receptor A7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epha7 |
| Official Name | Eph receptor A7 [Source:RGD Symbol;Acc:70957] |
| Ensembl ID | ENSRNOG00000007030 |
| Bio databases IDs | |
| Aliases | Eph receptor A7 |
| Synonyms | Cek11, Ebk, EHK-3, EK11, EPH receptor A7, Ephrin a7, HEK11, Mdk1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epha7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tyrosine-protein kinase ephrin type A/B receptor-like
- chemorepellant
- ephrin receptor binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- GPI-linked ephrin receptor
- Sterile alpha motif
- cytoplasmic domain
- SAM domain (Sterile alpha motif)
- intracellular domain
- Tyrosine kinase, catalytic domain
- growth factor binding
- Ligand Binding Domain of Ephrin Receptors
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- axon guidance receptor
- SAM (Sterile alpha motif )
- Purple acid Phosphatase, N-terminal domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- FN3
- cytosolic tail domain
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the Epha7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- chronic fatigue syndrome
- portal hypertension
- proliferative diabetic retinopathy
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- Cornelia de Lange syndrome
- anencephaly
regulates
- ERK
- L-tyrosine
role in cell
- apoptosis
- quantity
- abnormal morphology
- formation
- length
- guidance
- complexity
- condensation
- development
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- cell-cell contacts
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- neuromuscular junctions
- synapse
- perikaryon
- dendrites
- dendritic shafts
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epha7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- retinal ganglion cell axon guidance
- regulation of cell-cell adhesion
- axon guidance
- branching morphogenesis of a nerve
- brain development
- protein phosphorylation
- positive regulation of neuron apoptotic process
- negative regulation of collateral sprouting
- regulation of peptidyl-tyrosine phosphorylation
- regulation of ERK1 and ERK2 cascade
- regulation of cysteine-type endopeptidase activity involved in apoptotic process
- nephric duct morphogenesis
- positive regulation of protein phosphorylation
- ephrin receptor signaling pathway
- regulation of synaptic transmission
- phosphorylation
- regulation of protein autophosphorylation
- neuron apoptotic process
- negative regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- dendrite
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- growth factor binding
- protein binding
- chemorepellent activity
- axon guidance receptor activity
- GPI-linked ephrin receptor activity
- transmembrane-ephrin receptor activity