Psmc6 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Involved in positive regulation of inclusion body assembly. Located in inclusion body. Part of cytosolic proteasome complex. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmc6 |
| Official Name | proteasome 26S subunit, ATPase 6 [Source:RGD Symbol;Acc:1308825] |
| Ensembl ID | ENSRNOG00000007203 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, ATPase 6 |
| Synonyms | 2300001E01Rik, CADP44, LOC100365869, p42, proteasome 26S subunit, ATPase 6, proteasome (prosome, macropain) 26S subunit, ATPase, 6, RPT4, RPT5, SUG2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Psmc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 26S proteasome subunit P45 family
- Proteasomal ATPase OB C-terminal domain
- ATPase family associated with various cellular activities (AAA)
- peptidase
- isomerase
- protein binding
- identical protein binding
- AAA+ lid domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Psmc6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- nonalcoholic fatty liver disease
regulates
- 26S proteasome
- HTT
- 19S proteasome
- PRKN
role in cell
- cell death
- quantity
- assembly in
- aggregation in
- assembly
- lipotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intracellular space
- cytosol
- nucleoplasm
- cytoplasmic droplets
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Psmc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of inclusion body assembly
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- proteasome regulatory particle, base subcomplex
- membrane
- cytosol
- cytosolic proteasome complex
- proteasome complex
- proteasome accessory complex
- inclusion body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein binding
- protein binding, bridging