Ldlr Gene Summary [Rat]
Enables low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Located in caveola and recycling endosome membrane. Used to study aortic atherosclerosis; atherosclerosis; familial hyperlipidemia; steatotic liver disease; and xanthomatosis. Biomarker of metabolic dysfunction and alcohol associated liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ldlr |
| Official Name | low density lipoprotein receptor [Source:RGD Symbol;Acc:2998] |
| Ensembl ID | ENSRNOG00000009946 |
| Bio databases IDs | |
| Aliases | low density lipoprotein receptor |
| Synonyms | FH, FHC, FHCL1, Hlb301, LDLCQ2, LDLRA, low density lipoprotein receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ldlr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein interaction domain
- O-linked glycosylation site
- clathrin binding
- low-density lipoprotein binding
- identical protein binding
- EGF_CA
- NPXY motif
- N-linked glycosylation site
- cytoplasmic domain
- ligand-binding domain
- intracellular domain
- LDLa
- tail domain
- Coagulation Factor Xa inhibitory site
- extracellular domain
- beta propeller
- protease binding
- ectodomain
- Epidermal growth factor precursor homology domain
- O-linked sugar region
- protein binding
- Low-density lipoprotein receptor repeat class B
- very-low-density lipoprotein receptor
- beta-amyloid binding
- EGF-like domain
- sorting signal domain
- transmembrane/cytoplasmic domain
- cytosolic tail domain
- low-density lipoprotein receptor
- Low-density lipoprotein-receptor YWTD domain
- transporter
Pathways
Biological processes and signaling networks where the Ldlr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- atherosclerosis
- fibrosis
- diabetic nephropathy
- coronary disease
- edema
- familial hypercholesterolemia
- familial hyperlipoproteinemia type IIa
- atherogenesis
- plaque psoriasis
role in cell
- cell death
- expression in
- accumulation in
- production in
- apoptosis
- cellular infiltration by
- necrosis
- proliferation
- activation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- pH resistant lipid raft fraction
- proximal axon
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- apical compartment
- somatodendritic region
- perinuclear region
- membrane surface
- cellular membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- granules
- basolateral cytoplasm
- plasma membrane extracellular face
- apical membrane
- caveolae
- basolateral membrane
- lateral plasma membrane
- pre-lysosomal compartments
- lysosome membrane
- endosomal membrane
- growth cone
- recycling endosomes
- early endosomes
- late endosomes
- endocytotic vesicle
- clathrin-coated pits
- dendrites
- sorting endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ldlr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cholesterol import
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
- cholesterol metabolic process
- lipoprotein catabolic process
- cholesterol homeostasis
- regulation of protein metabolic process
- beta-amyloid clearance
- cellular response to fatty acid
- negative regulation of receptor recycling
- regulation of phosphatidylcholine catabolic process
- cholesterol transport
- negative regulation of protein metabolic process
- low-density lipoprotein particle clearance
- plasma lipoprotein particle clearance
- positive regulation of inflammatory response
- high-density lipoprotein particle clearance
- artery morphogenesis
- endocytosis
- receptor-mediated endocytosis
- regulation of cholesterol metabolic process
- long-term memory
- negative regulation of gene expression
- negative regulation of low-density lipoprotein particle clearance
- positive regulation of triglyceride biosynthetic process
- positive regulation of gene expression
- lipid metabolic process
- phagocytosis
- phospholipid transport
- intestinal cholesterol absorption
- cellular response to low-density lipoprotein particle stimulus
Cellular Component
Where in the cell the gene product is active
- endolysosome membrane
- low-density lipoprotein particle
- late endosome
- external side of plasma membrane
- Golgi apparatus
- receptor complex
- plasma membrane
- cell surface
- lysosome
- early endosome
- clathrin-coated endocytic vesicle membrane
- apical part of cell
- coated pit
- membrane
- endosome membrane
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- clathrin heavy chain binding
- identical protein binding
- low-density lipoprotein receptor activity
- protease binding
- beta-amyloid binding
- very-low-density lipoprotein particle receptor activity
- protein binding
- calcium ion binding
- viral receptor activity
- low-density lipoprotein particle binding
- lipoprotein particle binding
- binding, bridging