Rad51 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; DNA binding activity; and catalytic activity, acting on DNA. Involved in several processes, including cellular response to cisplatin; cellular response to gamma radiation; and response to X-ray. Predicted to be located in several cellular components, including chromosome; male germ cell nucleus; and nuclear lumen. Predicted to be part of nuclear ubiquitin ligase complex. Predicted to be active in presynaptic intermediate filament cytoskeleton and site of double-strand break. Used to study cardiomyopathy and hypertension. Biomarker of pancreatic cancer. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad51 |
| Official Name | RAD51 recombinase [Source:RGD Symbol;Acc:1563603] |
| Ensembl ID | ENSRNOG00000037302 |
| Bio databases IDs | |
| Aliases | RAD51 recombinase |
| Synonyms | BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RAD51 recombinase, RECA, RECA-LIKE, RGD1563603 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rad51 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- Helix-hairpin-helix domain
- DNA repair and recombination protein RadA
- meiotic recombinase Dmc1
- ATP-binding domain
- ATP binding
- Rad51
- enzyme binding
- chromatin binding
- enzyme
- protein binding
- DNA repair protein RAD51
- identical protein binding
- AAA domain
- DNA repair and recombination protein RadB
- recA bacterial DNA recombination protein
- single-stranded DNA binding
- double-stranded DNA binding
- recombinase
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rad51 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- acute myeloid leukemia
- hepatocellular carcinoma
- acute coronary syndrome
- epithelial neoplasia
- squamous cell cancer
- epithelial cancer
- liver cancer
- head and neck squamous cell cancer
- esophageal adenocarcinoma
role in cell
- accumulation in
- cell death
- expression in
- phosphorylation in
- migration
- apoptosis
- proliferation
- growth
- cell viability
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- intermediate filament cytoskeleton
- cytoskeleton
- Cytoplasm
- perinuclear region
- Mitochondria
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- perinuclear space
- nucleoli
- nuclear bodies
- PML nuclear bodies
- chromatin foci
- synaptonemal complexes
- telomeres
- chromatin
- chromosomal cores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rad51 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- reciprocal meiotic recombination
- double-strand break repair via homologous recombination
- DNA recombination
- telomere maintenance via recombination
- response to DNA damage stimulus
- chromosome organization involved in meiosis
- DNA recombinase assembly
- strand invasion
- DNA unwinding involved in replication
- mitotic recombination
- meiotic cell cycle
- regulation of protein phosphorylation
- cellular response to ionizing radiation
- cellular response to hydroxyurea
- regulation of DNA damage checkpoint
- regulation of double-strand break repair via homologous recombination
- replication fork processing
- telomere maintenance via telomere lengthening
- positive regulation of DNA ligation
Cellular Component
Where in the cell the gene product is active
- site of double-strand break
- PML body
- nuclear chromosome
- lateral element
- nucleolus
- chromatin
- male germ cell nucleus
- nucleoplasm
- condensed nuclear chromosome
- condensed chromosome
- nucleus
- chromosome, telomeric region
- centrosome
- perinuclear region of cytoplasm
- nuclear ubiquitin ligase complex
- mitochondrial matrix
- cytoplasm
- mitochondrion
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- identical protein binding
- DNA-dependent ATPase activity
- double-stranded DNA binding
- chromatin binding
- single-stranded DNA binding
- ATP binding
- DNA polymerase binding
- protein binding
- recombinase activity
- single-stranded DNA-dependent ATP-dependent DNA helicase activity
- enzyme binding