Psmc6 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and proteasome-activating activity. Predicted to be involved in positive regulation of cellular component biogenesis and proteasomal protein catabolic process. Part of proteasome accessory complex. Is expressed in several structures, including brain; genitourinary system; gut; integumental system; and vascular system. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmc6 |
| Official Name | proteasome (prosome, macropain) 26S subunit, ATPase, 6 [Source:MGI Symbol;Acc:MGI:1914339] |
| Ensembl ID | ENSMUSG00000021832 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) 26S subunit, ATPase, 6 |
| Synonyms | 2300001E01Rik, CADP44, LOC100365869, p42, proteasome 26S subunit, ATPase 6, proteasome (prosome, macropain) 26S subunit, ATPase, 6, RPT4, RPT5, SUG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 26S proteasome subunit P45 family
- Proteasomal ATPase OB C-terminal domain
- ATPase family associated with various cellular activities (AAA)
- peptidase
- isomerase
- protein binding
- identical protein binding
- AAA+ lid domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Psmc6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- nonalcoholic fatty liver disease
role in cell
- cell death
- quantity
- assembly in
- aggregation in
- assembly
- lipotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intracellular space
- cytosol
- nucleoplasm
- cytoplasmic droplets
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of inclusion body assembly
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- proteasome regulatory particle, base subcomplex
- membrane
- cytosol
- cytosolic proteasome complex
- proteasome complex
- proteasome accessory complex
- inclusion body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein binding
- protein binding, bridging